Walt and Jesse are vividly reminded of Tuco’s volatile nature, and try to figure a way out of their business partnership. Hank attempts to mend fences between the estranged Marie and Skyler.
Walt and Jesse find themselves in close quarters with an unhinged Tuco. Marie and Hank comfort Skyler, who is distraught over Walt’s disappearance. Hank pays a visit to Mrs. Pinkman on some not-so-official business.
Walt and Jesse cover their tracks, but as a result, both of their financial situations suffer. Meanwhile, Hank and his DEA colleagues may have a break in their meth investigation.
Walt tries to reconnect with his family. Still suspicious of her husband's actions, Skyler keeps her distance. Jesse finds himself without a place to live and struggles to cope.
Tensions and bills mount at the White household. Hank makes progress at work, but struggles with some residual effects from his encounter with Tuco. Jesse takes charge and assembles a crew of dealers to get their product out on the streets.
Walt returns to work. Skinny Pete gets ripped off and when Jesse steps in to "handle it," he gets more than he bargained for. Skyler finally gets to thank Gretchen for paying for Walt's treatment.
Rumors fly about Jesse's recent actions as he and Walt discuss expanding their business into new territories. Hank struggles to fit in with his new co-workers in El Paso. Skyler pursues a new job opportunity that reconnects her with a former colleague. Jesse gets to know his landlord, Jane.
When Badger finds himself in trouble with the law, Walt and Jesse seek the legal advice of a shady attorney, Saul Goodman. The DEA believe they may have finally caught up with the elusive 'Heisenberg.' Hank returns to Albuquerque, but his troubled mental state and demeanor cause Marie to worry.
After Walt undergoes a PET-CT scan, he and his family wait for news about his cancer treatment progress. Fearing the worst, Walt follows Saul's advice to cook as much product as he can with the time he has left. Jesse's relationship with Jane develops, but is put on hold when he and Walt retreat to the desert for their marathon cook.
Walt and Hank get into a heated argument at a party the Whites host to thank friends and family for their support over the last few months. A stir-crazy Walt consumes himself with home improvements. Skyler is emotional and conflicted about Walt's treatment and opens up to her boss, Ted. Jane hides her relationship with Jesse from her father.
When Walt and Jesse's crew of dealers begins to dwindle, Saul proposes a new business partner. Meanwhile, Skyler makes a disturbing discovery at work and confronts Ted. Jesse divulges his real profession to Jane, and their relationship takes a dangerous turn.
The Whites welcome a new addition. Walter Jr. launches a new website in an effort to aid his struggling family. Jesse's addiction begins to spiral out of control. Jane and Jesse's relationship leads to friction with both Walt and Donald.
Skyler and Walt collide in the season finale as her frustration with his secrecy finally comes to a head. Jesse self-destructs after a personal blow, forcing Walt to come to his aid. Donald's grief leads to tragedy.